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Tuesday, April 8, 2025

West Road Concert Hall
12:00 PM - 5:00 PM
Registration Open
12:30 PM - 1:45 PM
Lunch and refreshments avalable
1:45 PM - 2:00 PM
Official Opening & Welcome Address
2:00 PM - 3:20 PM Facing the Complexity of Synucleinopathies

Moderator: David Dexter

PD and MSA
Werner Poewe, Professor of Neurology, Medical University Innsbruck (in honour of Gregor Wenning)

Prodromal synucleinopathies
Michele Hu , Professor of Clinical Neuroscience, University of Oxford

Genetic Complexity of PD
John Hardy, Professor, Chair of Molecular Biology of Neurological Disease at the UCL Institute of Neurology, University College London

Clinical-imaging subtypes of PD
Per Borghammer, Professor, Dep. of Nuclear Medicine & PET, Aarhus University Hospital
3:20 PM - 3:45 PM
Refreshments day 1
3:45 PM - 4:30 PM Round Table: Perspectives from people with Parkinson's

Moderator: Caroline Williams-Gray, University of Cambridge and George Tofaris, University of Oxford

Participants:
Trevor Elliott
Jan Kish
Neil Russell
David Stocker
4:35 PM - 5:15 PM A Historical Perspective of αSyn in PD

Moderator: Leonidas Stefanis

The Road to the First SNCA Mutation
Lawrence Golbe, Emeritus Professor of Neurology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey

Alpha-Synuclein and its identification in Lewy bodies and Lewy neurites
Maria Grazia Spillantini, Professor of Molecular Neurology, University of Cambridge
5:45 PM - 7:30 PM Welcome Reception
Located in the heart of Cambridge (a 20-minute walk away), just off Downing Street, the Whale Hall of The Museum of Zoology, will be the venue for the welcome reception providing a unique and memorable experience. Please note the Welcome Reception is sold out.
West Road Concert Hall
12:00 PM - 5:00 PM
Registration Open
12:30 PM - 1:45 PM
Lunch and refreshments avalable
1:45 PM - 2:00 PM
Official Opening & Welcome Address
2:00 PM - 3:20 PM Facing the Complexity of Synucleinopathies

Moderator: David Dexter

PD and MSA
Werner Poewe, Professor of Neurology, Medical University Innsbruck (in honour of Gregor Wenning)

Prodromal synucleinopathies
Michele Hu , Professor of Clinical Neuroscience, University of Oxford

Genetic Complexity of PD
John Hardy, Professor, Chair of Molecular Biology of Neurological Disease at the UCL Institute of Neurology, University College London

Clinical-imaging subtypes of PD
Per Borghammer, Professor, Dep. of Nuclear Medicine & PET, Aarhus University Hospital
3:20 PM - 3:45 PM
Refreshments day 1
3:45 PM - 4:30 PM Round Table: Perspectives from people with Parkinson's

Moderator: Caroline Williams-Gray, University of Cambridge and George Tofaris, University of Oxford

Participants:
Trevor Elliott
Jan Kish
Neil Russell
David Stocker
4:35 PM - 5:15 PM A Historical Perspective of αSyn in PD

Moderator: Leonidas Stefanis

The Road to the First SNCA Mutation
Lawrence Golbe, Emeritus Professor of Neurology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey

Alpha-Synuclein and its identification in Lewy bodies and Lewy neurites
Maria Grazia Spillantini, Professor of Molecular Neurology, University of Cambridge
5:45 PM - 7:30 PM Welcome Reception
Located in the heart of Cambridge (a 20-minute walk away), just off Downing Street, the Whale Hall of The Museum of Zoology, will be the venue for the welcome reception providing a unique and memorable experience. Please note the Welcome Reception is sold out.

West Road Concert Hall
12:00 PM - 5:00 PM
Registration Open
12:30 PM - 1:45 PM
Lunch and refreshments avalable
1:45 PM - 2:00 PM
Official Opening & Welcome Address
2:00 PM - 3:20 PM Facing the Complexity of Synucleinopathies

Moderator: David Dexter

PD and MSA
Werner Poewe, Professor of Neurology, Medical University Innsbruck (in honour of Gregor Wenning)

Prodromal synucleinopathies
Michele Hu , Professor of Clinical Neuroscience, University of Oxford

Genetic Complexity of PD
John Hardy, Professor, Chair of Molecular Biology of Neurological Disease at the UCL Institute of Neurology, University College London

Clinical-imaging subtypes of PD
Per Borghammer, Professor, Dep. of Nuclear Medicine & PET, Aarhus University Hospital
3:20 PM - 3:45 PM
Refreshments day 1
3:45 PM - 4:30 PM Round Table: Perspectives from people with Parkinson's

Moderator: Caroline Williams-Gray, University of Cambridge and George Tofaris, University of Oxford

Participants:
Trevor Elliott
Jan Kish
Neil Russell
David Stocker
4:35 PM - 5:15 PM A Historical Perspective of αSyn in PD

Moderator: Leonidas Stefanis

The Road to the First SNCA Mutation
Lawrence Golbe, Emeritus Professor of Neurology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey

Alpha-Synuclein and its identification in Lewy bodies and Lewy neurites
Maria Grazia Spillantini, Professor of Molecular Neurology, University of Cambridge
5:45 PM - 7:30 PM Welcome Reception
Located in the heart of Cambridge (a 20-minute walk away), just off Downing Street, the Whale Hall of The Museum of Zoology, will be the venue for the welcome reception providing a unique and memorable experience. Please note the Welcome Reception is sold out.

Wednesday, April 9, 2025

West Road Concert Hall
8:00 AM - 6:00 PM
Conference desk opens
8:30 AM - 10:00 AM Physiology and Interactome

Moderator: Pam McLean, Mayo Clinic

VAMP2 regulates alpha-synuclein phase separation
 Janin Lautenschlaeger, Principal Investigator and Royal Society Dorothy Hodgkin Research Fellow, Cambridge Institute for Medical Research (CIMR), University of Cambridge

Selected abstracts:
Distinguishing α-synuclein serine-129 phosphorylation in health and Lewy body diseases
Nagendran Ramalingam, Brigham & Women's Hospital and Harvard Medical School

G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s Disease pathogenesis
Scott Ryan, University of Calgary

A new paradigm for investigating synucleinopathy therapeutic targets and biomarkers: approaching synucleinopathies as lipidopathies.
Saranna Fanning, Harvard Medical School and Brigham & Women's Hospital

Lipidomic Profiling Reveals Shared and Distinct Pathological Signatures in Sporadic Parkinson's Disease and GBA Mutation Carriers
Céline Galvagnion, University of Copenhagen

Panel Discussion
10:00 AM - 10:30 AM
Refreshments and Day One Posters
10:30 AM - 12:00 PM Pathological Assembly

Moderator: Claudio Fernandez, MPLbioR (CEI-UNR/MPINAT-MPG)

Cryo-EM structures of alpha-synuclein filaments from the human brain.
Michel Goedert, Group Leader, MRC Laboratory of Molecular Biology

Alpha-synuclein aggregates polymorphism and the structural molecular basis of distinct synucleinopathies.
Ronald Melki, Research Director, CNRS; Institut Francois Jacob (MIRCen), CEA

Selected Abstracts:
Resolving heterogeneity of Lewy Bodies with spatial proteomics
Marc Oeller, Max Planck Institute of Biochemistry

Tuning the aggregation landscape of alpha-synuclein by the specific binding of a molecular probe to master controller sequences
Phelippe Do Carmo Gonçalves, Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario (MPLbioR, UNR-MPINAT)

Investigating the “structure-function” relationship of the intrinsically disordered regions of alpha-synuclein amyloid fibrils
Liam Aubrey, University of Leeds

Panel Discussion
12:00 PM - 1:20 PM
Lunch, Exhibition and Day One Posters
1:20 PM - 3:15 PM αSyn and Organelle Homeostasis

Moderator: Poul Henning Jensen

Parkinson’s Disease Revisited: A Disorder of Proteins, Organelles, or an Interplay of Both?
Hilal Lashuel, Director of the Laboratory of Chemical Biology of Neurodegeneration, Swiss Federal Institute of Technology Lausanne

Interplay between α-Synuclein and organelle homeostasis at the onset of Parkinson’s disease
George Tofaris, Professor of Neurology and Translational Neuroscience, University of Oxford

The dynamic cellular biology of alpha-synuclein
Ulf Dettmer, Associate Professor of Neurology, Harvard Medical School
Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital

Selected Abstracts:
Alpha-synuclein regulates the neuronal lipidome in synucleinopathies at the Mitochondria-Associated ER Membranes (MAM)
Peter Barbuti, Columbia University

Pharmacological correction of excessive basal mitophagy by pathological levels of α-synuclein restores neuronal function in human dopaminergic neurons
Elliot Mock, University of Oxford

A novel pathway underlying the dysregulation of alpha-synuclein in Parkinson’s disease
Eleanna Kara, Rutgers University

Panel Discussion
3:15 PM - 3:45 PM
Refreshments & Day One Posters
3:45 PM - 5:30 PM Advanced Microscopy for Studying Synucleinopathies

Moderators: Uri Ashery, Tel Aviv University

Super-resolution imaging
David Klenermann, Professor of Biophysical Chemistry, University of Cambridge

Cryo ET
Ruben Fernandez-Busnadiego, Professor, Institute of Neuropathology, University of Göttingen

A cellular perspective on alpha-synuclein pathology in the human brain
Wilma van de Berg, Senior Neuroscientist & Associate Professor, University of Amsterdam

Selected Abstracts:
Two-photon and confocal microscopy plus MRI and PET analysis disclose the earliest synaptic/connectome changes associated with pathological alpha-synuclein deposition
Gaia Faustini, University of Brescia

New pathological phenotype identified in MSA post-mortem human brain using CLEM
Amanda Lewis, Laboratory of Biological Electron Microscopy, EPFL and Department of Fundamental Microbiology, UNIL

Unveiling alpha-Synuclein Assemblies: Modeling and Cutting-Edge Imaging Techniques to Unravel Disease Mechanisms
Diana Lazaro, University of Pennsylvania

Panel Discussion
West Road Concert Hall
8:00 AM - 6:00 PM
Conference desk opens
8:30 AM - 10:00 AM Physiology and Interactome

Moderator: Pam McLean, Mayo Clinic

VAMP2 regulates alpha-synuclein phase separation
 Janin Lautenschlaeger, Principal Investigator and Royal Society Dorothy Hodgkin Research Fellow, Cambridge Institute for Medical Research (CIMR), University of Cambridge

Selected abstracts:
Distinguishing α-synuclein serine-129 phosphorylation in health and Lewy body diseases
Nagendran Ramalingam, Brigham & Women's Hospital and Harvard Medical School

G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s Disease pathogenesis
Scott Ryan, University of Calgary

A new paradigm for investigating synucleinopathy therapeutic targets and biomarkers: approaching synucleinopathies as lipidopathies.
Saranna Fanning, Harvard Medical School and Brigham & Women's Hospital

Lipidomic Profiling Reveals Shared and Distinct Pathological Signatures in Sporadic Parkinson's Disease and GBA Mutation Carriers
Céline Galvagnion, University of Copenhagen

Panel Discussion
10:00 AM - 10:30 AM
Refreshments and Day One Posters
10:30 AM - 12:00 PM Pathological Assembly

Moderator: Claudio Fernandez, MPLbioR (CEI-UNR/MPINAT-MPG)

Cryo-EM structures of alpha-synuclein filaments from the human brain.
Michel Goedert, Group Leader, MRC Laboratory of Molecular Biology

Alpha-synuclein aggregates polymorphism and the structural molecular basis of distinct synucleinopathies.
Ronald Melki, Research Director, CNRS; Institut Francois Jacob (MIRCen), CEA

Selected Abstracts:
Resolving heterogeneity of Lewy Bodies with spatial proteomics
Marc Oeller, Max Planck Institute of Biochemistry

Tuning the aggregation landscape of alpha-synuclein by the specific binding of a molecular probe to master controller sequences
Phelippe Do Carmo Gonçalves, Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario (MPLbioR, UNR-MPINAT)

Investigating the “structure-function” relationship of the intrinsically disordered regions of alpha-synuclein amyloid fibrils
Liam Aubrey, University of Leeds

Panel Discussion
12:00 PM - 1:20 PM
Lunch, Exhibition and Day One Posters
1:20 PM - 3:15 PM αSyn and Organelle Homeostasis

Moderator: Poul Henning Jensen

Parkinson’s Disease Revisited: A Disorder of Proteins, Organelles, or an Interplay of Both?
Hilal Lashuel, Director of the Laboratory of Chemical Biology of Neurodegeneration, Swiss Federal Institute of Technology Lausanne

Interplay between α-Synuclein and organelle homeostasis at the onset of Parkinson’s disease
George Tofaris, Professor of Neurology and Translational Neuroscience, University of Oxford

The dynamic cellular biology of alpha-synuclein
Ulf Dettmer, Associate Professor of Neurology, Harvard Medical School
Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital

Selected Abstracts:
Alpha-synuclein regulates the neuronal lipidome in synucleinopathies at the Mitochondria-Associated ER Membranes (MAM)
Peter Barbuti, Columbia University

Pharmacological correction of excessive basal mitophagy by pathological levels of α-synuclein restores neuronal function in human dopaminergic neurons
Elliot Mock, University of Oxford

A novel pathway underlying the dysregulation of alpha-synuclein in Parkinson’s disease
Eleanna Kara, Rutgers University

Panel Discussion
3:15 PM - 3:45 PM
Refreshments & Day One Posters
3:45 PM - 5:30 PM Advanced Microscopy for Studying Synucleinopathies

Moderators: Uri Ashery, Tel Aviv University

Super-resolution imaging
David Klenermann, Professor of Biophysical Chemistry, University of Cambridge

Cryo ET
Ruben Fernandez-Busnadiego, Professor, Institute of Neuropathology, University of Göttingen

A cellular perspective on alpha-synuclein pathology in the human brain
Wilma van de Berg, Senior Neuroscientist & Associate Professor, University of Amsterdam

Selected Abstracts:
Two-photon and confocal microscopy plus MRI and PET analysis disclose the earliest synaptic/connectome changes associated with pathological alpha-synuclein deposition
Gaia Faustini, University of Brescia

New pathological phenotype identified in MSA post-mortem human brain using CLEM
Amanda Lewis, Laboratory of Biological Electron Microscopy, EPFL and Department of Fundamental Microbiology, UNIL

Unveiling alpha-Synuclein Assemblies: Modeling and Cutting-Edge Imaging Techniques to Unravel Disease Mechanisms
Diana Lazaro, University of Pennsylvania

Panel Discussion

West Road Concert Hall
8:00 AM - 6:00 PM
Conference desk opens
8:30 AM - 10:00 AM Physiology and Interactome

Moderator: Pam McLean, Mayo Clinic

VAMP2 regulates alpha-synuclein phase separation
 Janin Lautenschlaeger, Principal Investigator and Royal Society Dorothy Hodgkin Research Fellow, Cambridge Institute for Medical Research (CIMR), University of Cambridge

Selected abstracts:
Distinguishing α-synuclein serine-129 phosphorylation in health and Lewy body diseases
Nagendran Ramalingam, Brigham & Women's Hospital and Harvard Medical School

G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s Disease pathogenesis
Scott Ryan, University of Calgary

A new paradigm for investigating synucleinopathy therapeutic targets and biomarkers: approaching synucleinopathies as lipidopathies.
Saranna Fanning, Harvard Medical School and Brigham & Women's Hospital

Lipidomic Profiling Reveals Shared and Distinct Pathological Signatures in Sporadic Parkinson's Disease and GBA Mutation Carriers
Céline Galvagnion, University of Copenhagen

Panel Discussion
10:00 AM - 10:30 AM
Refreshments and Day One Posters
10:30 AM - 12:00 PM Pathological Assembly

Moderator: Claudio Fernandez, MPLbioR (CEI-UNR/MPINAT-MPG)

Cryo-EM structures of alpha-synuclein filaments from the human brain.
Michel Goedert, Group Leader, MRC Laboratory of Molecular Biology

Alpha-synuclein aggregates polymorphism and the structural molecular basis of distinct synucleinopathies.
Ronald Melki, Research Director, CNRS; Institut Francois Jacob (MIRCen), CEA

Selected Abstracts:
Resolving heterogeneity of Lewy Bodies with spatial proteomics
Marc Oeller, Max Planck Institute of Biochemistry

Tuning the aggregation landscape of alpha-synuclein by the specific binding of a molecular probe to master controller sequences
Phelippe Do Carmo Gonçalves, Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario (MPLbioR, UNR-MPINAT)

Investigating the “structure-function” relationship of the intrinsically disordered regions of alpha-synuclein amyloid fibrils
Liam Aubrey, University of Leeds

Panel Discussion
12:00 PM - 1:20 PM
Lunch, Exhibition and Day One Posters
1:20 PM - 3:15 PM αSyn and Organelle Homeostasis

Moderator: Poul Henning Jensen

Parkinson’s Disease Revisited: A Disorder of Proteins, Organelles, or an Interplay of Both?
Hilal Lashuel, Director of the Laboratory of Chemical Biology of Neurodegeneration, Swiss Federal Institute of Technology Lausanne

Interplay between α-Synuclein and organelle homeostasis at the onset of Parkinson’s disease
George Tofaris, Professor of Neurology and Translational Neuroscience, University of Oxford

The dynamic cellular biology of alpha-synuclein
Ulf Dettmer, Associate Professor of Neurology, Harvard Medical School
Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital

Selected Abstracts:
Alpha-synuclein regulates the neuronal lipidome in synucleinopathies at the Mitochondria-Associated ER Membranes (MAM)
Peter Barbuti, Columbia University

Pharmacological correction of excessive basal mitophagy by pathological levels of α-synuclein restores neuronal function in human dopaminergic neurons
Elliot Mock, University of Oxford

A novel pathway underlying the dysregulation of alpha-synuclein in Parkinson’s disease
Eleanna Kara, Rutgers University

Panel Discussion
3:15 PM - 3:45 PM
Refreshments & Day One Posters
3:45 PM - 5:30 PM Advanced Microscopy for Studying Synucleinopathies

Moderators: Uri Ashery, Tel Aviv University

Super-resolution imaging
David Klenermann, Professor of Biophysical Chemistry, University of Cambridge

Cryo ET
Ruben Fernandez-Busnadiego, Professor, Institute of Neuropathology, University of Göttingen

A cellular perspective on alpha-synuclein pathology in the human brain
Wilma van de Berg, Senior Neuroscientist & Associate Professor, University of Amsterdam

Selected Abstracts:
Two-photon and confocal microscopy plus MRI and PET analysis disclose the earliest synaptic/connectome changes associated with pathological alpha-synuclein deposition
Gaia Faustini, University of Brescia

New pathological phenotype identified in MSA post-mortem human brain using CLEM
Amanda Lewis, Laboratory of Biological Electron Microscopy, EPFL and Department of Fundamental Microbiology, UNIL

Unveiling alpha-Synuclein Assemblies: Modeling and Cutting-Edge Imaging Techniques to Unravel Disease Mechanisms
Diana Lazaro, University of Pennsylvania

Panel Discussion

Thursday, April 10, 2025

West Road Concert Hall
8:00 AM - 6:00 PM
Conference desk opens day 3
8:30 AM - 10:25 AM αSyn and the Immune System

Moderator: Kelvin Luk, University of Pennsylvania

The role of tissue resident macrophages in T cell mediated neurodegeneration
Ashley Harms, Associate Professor, Centre for Neurodegeneration and Experimental Therapeutics. Department of Neurology, The University of Alabama at Birmingham

Targeting immune activation - a new therapeutic approach in Parkinson's disease?
Caroline Williams-Gray, Principal Research Associate, Department of Clinical Neurosciences, University of Cambridge

Does Peripheral Immune response differ in Parkinson subtypes? Marina Romero-Ramos, Professor, Department of Biomedicine, Aarhus University

Selected Abstracts:
 From gut to brain: T cells from inflammatory bowel disease patients accumulate in brain tissue and induce Parkinson's disease-like pathology
Elizaveta Gerasimova, University Hospital Erlangen

Immunoproteasome Dysregulation and Therapeutic Potential in Parkinson’s Disease and Multiple System Atrophy
Huu Dat Nguyen, Hallym University Sacred Heart Hospital

α-Synuclein induces macrophage M1 polarization and sequential selective dysfunction of enteric neurons in the colon of Parkinson’s disease model
Wen Li, China Medical University

Panel Discussion
10:25 AM - 11:00 AM
Refreshments, Exhibition and Day Two Posters
11:00 AM - 12:55 PM αSyn Spreading and Periphery

Moderator: Ayse Ulusoy, Group Leader, German Center for Neurodegenerative Diseases

T-cells and gut macrophages as modulators in body-first Parkinson’s Disease
Tim Bartels, Group Leader, UK Dementia Research Institute; Associate Professor, University College London

Oxidative/nitrative stress promotes alpha-synuclein spreading in vivo
Donato A. Di Monte, Senior Group Leader, German Center for Neurodegenerative Diseases (DZNE)

Modeling alpha-synuclein propagation and neurotoxicity in rodent brain
Veerle Baekelandt, Professor, KU Leuven

Selected Abstracts:
Alpha-synuclein prion strains differentially adapt after passage in mice
Amanda Woerman, Colorado State University

Periphery to brain spreading of a-syn in novel PD mouse models
Pauline Vessiere, University of Cambridge

Molecular signatures of altered energy metabolism and circadian rhythm perturbations in a model of alpha-Synucleinopathy
Asad Jan, Aarhus University, Denmark

Panel Discussion
12:55 PM - 2:15 PM
Lunch, Exhibition and Day Two Posters
2:15 PM - 4:00 PM αSyn Biomarkers SAA

Moderator: Evangelia Emmanouilidou, National and Kapodistrian University of Athens

Alpha-synucelin seed amplification assay: Applications for diagnosis, drug discovery and to understand disease mechanisms
Claudio Soto, Professor, University of Texas Medical School

Selected Abstracts:
Quantitative Measurements of α-Synuclein Seeds in CSF Inform Diagnosis and Staging of Synucleinopathies
Omar El-Agnaf, Qatar Biomedical Research Institute, HBKU, Qatar Foundation

Single extracellular vesicle detection assay identifies membrane-associated a-Synuclein as an early-stage biomarker in Parkinson’s disease
Shijun Yan, University of Oxford

Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles Laura Parkkinen, University of Oxford

Structural insight into binding of novel PET tracer MODAG-005 to lipidic 𝛼-Synuclein fibrils
Myeongkyu Kim, Max Planck Institute for Multidisciplinary Sciences

Dual 4R-Tau and α-Synuclein Seed Amplification Assays for Differential Diagnosis of Movement Disorders
Ivan Martinez-Valbuena, Tanz Centre for Research in Neurodegenerative diseases - University of Toronto

Panel Discussion
4:00 PM - 4:30 PM
Refreshments and Day Two Posters
4:30 PM - 6:25 PM Modeling αSyn Pathology in Experimental Models

Moderator: Jia-Yi Li, Department of Experimental Medical Science, Lund University
Alpha-synuclein in Lewy Bodies
Virginia M-Y Lee, The John H. Ware 3rd Endowed Professor in Alzheimer's Research, Director, Centre for Neurodegenerative Disease Research, University of Pennsylvania

Experimental models of MSA
Nadia Stefanova, Professor at Department of Neurology, Medical University of Innsbruck, Austria

Alpha-synuclein causes tau-dependent synaptic deficits: Mechanistic insights for Lewy body dementia
Michael Lee, Center for Neurodegenerative Disease, Institute for Translational Neuroscience, The University of Minnesota

Selected Abstracts:
Network analysis of α-synuclein progression identifies p21-activated kinases as therapeutic targets for Parkinson’s disease
Michael Henderson, Van Andel Institute

Intranasally administered exosomes containing α-synuclein induce behavioural deficits and brain pathology in vivo but are protected by heterozygous Drp1 knockout
Harry Brown, Florida International University

Diabetes-Driven Neurodegeneration: IDE Deficiency and High-Fat Diet as Key Contributors to Parkinson’s Disease Neuropathology
Hugo Vincente Miranda, NOVA University Lisbon

Panel Discussion
7:30 PM - 10:30 PM GALA DINNER
The main dining hall of the world-famous King’s College will host the conference gala dinner, a venue that perfectly befits the importance of Synuclein 2025. Guests will be treated to an exceptional experience against the backdrop of the iconic King’s College Chapel, which took around 100 years to build.

Please note the Gala Dinner is sold out and we have put a waiting list in place.
West Road Concert Hall
8:00 AM - 6:00 PM
Conference desk opens day 3
8:30 AM - 10:25 AM αSyn and the Immune System

Moderator: Kelvin Luk, University of Pennsylvania

The role of tissue resident macrophages in T cell mediated neurodegeneration
Ashley Harms, Associate Professor, Centre for Neurodegeneration and Experimental Therapeutics. Department of Neurology, The University of Alabama at Birmingham

Targeting immune activation - a new therapeutic approach in Parkinson's disease?
Caroline Williams-Gray, Principal Research Associate, Department of Clinical Neurosciences, University of Cambridge

Does Peripheral Immune response differ in Parkinson subtypes? Marina Romero-Ramos, Professor, Department of Biomedicine, Aarhus University

Selected Abstracts:
 From gut to brain: T cells from inflammatory bowel disease patients accumulate in brain tissue and induce Parkinson's disease-like pathology
Elizaveta Gerasimova, University Hospital Erlangen

Immunoproteasome Dysregulation and Therapeutic Potential in Parkinson’s Disease and Multiple System Atrophy
Huu Dat Nguyen, Hallym University Sacred Heart Hospital

α-Synuclein induces macrophage M1 polarization and sequential selective dysfunction of enteric neurons in the colon of Parkinson’s disease model
Wen Li, China Medical University

Panel Discussion
10:25 AM - 11:00 AM
Refreshments, Exhibition and Day Two Posters
11:00 AM - 12:55 PM αSyn Spreading and Periphery

Moderator: Ayse Ulusoy, Group Leader, German Center for Neurodegenerative Diseases

T-cells and gut macrophages as modulators in body-first Parkinson’s Disease
Tim Bartels, Group Leader, UK Dementia Research Institute; Associate Professor, University College London

Oxidative/nitrative stress promotes alpha-synuclein spreading in vivo
Donato A. Di Monte, Senior Group Leader, German Center for Neurodegenerative Diseases (DZNE)

Modeling alpha-synuclein propagation and neurotoxicity in rodent brain
Veerle Baekelandt, Professor, KU Leuven

Selected Abstracts:
Alpha-synuclein prion strains differentially adapt after passage in mice
Amanda Woerman, Colorado State University

Periphery to brain spreading of a-syn in novel PD mouse models
Pauline Vessiere, University of Cambridge

Molecular signatures of altered energy metabolism and circadian rhythm perturbations in a model of alpha-Synucleinopathy
Asad Jan, Aarhus University, Denmark

Panel Discussion
12:55 PM - 2:15 PM
Lunch, Exhibition and Day Two Posters
2:15 PM - 4:00 PM αSyn Biomarkers SAA

Moderator: Evangelia Emmanouilidou, National and Kapodistrian University of Athens

Alpha-synucelin seed amplification assay: Applications for diagnosis, drug discovery and to understand disease mechanisms
Claudio Soto, Professor, University of Texas Medical School

Selected Abstracts:
Quantitative Measurements of α-Synuclein Seeds in CSF Inform Diagnosis and Staging of Synucleinopathies
Omar El-Agnaf, Qatar Biomedical Research Institute, HBKU, Qatar Foundation

Single extracellular vesicle detection assay identifies membrane-associated a-Synuclein as an early-stage biomarker in Parkinson’s disease
Shijun Yan, University of Oxford

Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles Laura Parkkinen, University of Oxford

Structural insight into binding of novel PET tracer MODAG-005 to lipidic 𝛼-Synuclein fibrils
Myeongkyu Kim, Max Planck Institute for Multidisciplinary Sciences

Dual 4R-Tau and α-Synuclein Seed Amplification Assays for Differential Diagnosis of Movement Disorders
Ivan Martinez-Valbuena, Tanz Centre for Research in Neurodegenerative diseases - University of Toronto

Panel Discussion
4:00 PM - 4:30 PM
Refreshments and Day Two Posters
4:30 PM - 6:25 PM Modeling αSyn Pathology in Experimental Models

Moderator: Jia-Yi Li, Department of Experimental Medical Science, Lund University
Alpha-synuclein in Lewy Bodies
Virginia M-Y Lee, The John H. Ware 3rd Endowed Professor in Alzheimer's Research, Director, Centre for Neurodegenerative Disease Research, University of Pennsylvania

Experimental models of MSA
Nadia Stefanova, Professor at Department of Neurology, Medical University of Innsbruck, Austria

Alpha-synuclein causes tau-dependent synaptic deficits: Mechanistic insights for Lewy body dementia
Michael Lee, Center for Neurodegenerative Disease, Institute for Translational Neuroscience, The University of Minnesota

Selected Abstracts:
Network analysis of α-synuclein progression identifies p21-activated kinases as therapeutic targets for Parkinson’s disease
Michael Henderson, Van Andel Institute

Intranasally administered exosomes containing α-synuclein induce behavioural deficits and brain pathology in vivo but are protected by heterozygous Drp1 knockout
Harry Brown, Florida International University

Diabetes-Driven Neurodegeneration: IDE Deficiency and High-Fat Diet as Key Contributors to Parkinson’s Disease Neuropathology
Hugo Vincente Miranda, NOVA University Lisbon

Panel Discussion
7:30 PM - 10:30 PM GALA DINNER
The main dining hall of the world-famous King’s College will host the conference gala dinner, a venue that perfectly befits the importance of Synuclein 2025. Guests will be treated to an exceptional experience against the backdrop of the iconic King’s College Chapel, which took around 100 years to build.

Please note the Gala Dinner is sold out and we have put a waiting list in place.

West Road Concert Hall
8:00 AM - 6:00 PM
Conference desk opens day 3
8:30 AM - 10:25 AM αSyn and the Immune System

Moderator: Kelvin Luk, University of Pennsylvania

The role of tissue resident macrophages in T cell mediated neurodegeneration
Ashley Harms, Associate Professor, Centre for Neurodegeneration and Experimental Therapeutics. Department of Neurology, The University of Alabama at Birmingham

Targeting immune activation - a new therapeutic approach in Parkinson's disease?
Caroline Williams-Gray, Principal Research Associate, Department of Clinical Neurosciences, University of Cambridge

Does Peripheral Immune response differ in Parkinson subtypes? Marina Romero-Ramos, Professor, Department of Biomedicine, Aarhus University

Selected Abstracts:
 From gut to brain: T cells from inflammatory bowel disease patients accumulate in brain tissue and induce Parkinson's disease-like pathology
Elizaveta Gerasimova, University Hospital Erlangen

Immunoproteasome Dysregulation and Therapeutic Potential in Parkinson’s Disease and Multiple System Atrophy
Huu Dat Nguyen, Hallym University Sacred Heart Hospital

α-Synuclein induces macrophage M1 polarization and sequential selective dysfunction of enteric neurons in the colon of Parkinson’s disease model
Wen Li, China Medical University

Panel Discussion
10:25 AM - 11:00 AM
Refreshments, Exhibition and Day Two Posters
11:00 AM - 12:55 PM αSyn Spreading and Periphery

Moderator: Ayse Ulusoy, Group Leader, German Center for Neurodegenerative Diseases

T-cells and gut macrophages as modulators in body-first Parkinson’s Disease
Tim Bartels, Group Leader, UK Dementia Research Institute; Associate Professor, University College London

Oxidative/nitrative stress promotes alpha-synuclein spreading in vivo
Donato A. Di Monte, Senior Group Leader, German Center for Neurodegenerative Diseases (DZNE)

Modeling alpha-synuclein propagation and neurotoxicity in rodent brain
Veerle Baekelandt, Professor, KU Leuven

Selected Abstracts:
Alpha-synuclein prion strains differentially adapt after passage in mice
Amanda Woerman, Colorado State University

Periphery to brain spreading of a-syn in novel PD mouse models
Pauline Vessiere, University of Cambridge

Molecular signatures of altered energy metabolism and circadian rhythm perturbations in a model of alpha-Synucleinopathy
Asad Jan, Aarhus University, Denmark

Panel Discussion
12:55 PM - 2:15 PM
Lunch, Exhibition and Day Two Posters
2:15 PM - 4:00 PM αSyn Biomarkers SAA

Moderator: Evangelia Emmanouilidou, National and Kapodistrian University of Athens

Alpha-synucelin seed amplification assay: Applications for diagnosis, drug discovery and to understand disease mechanisms
Claudio Soto, Professor, University of Texas Medical School

Selected Abstracts:
Quantitative Measurements of α-Synuclein Seeds in CSF Inform Diagnosis and Staging of Synucleinopathies
Omar El-Agnaf, Qatar Biomedical Research Institute, HBKU, Qatar Foundation

Single extracellular vesicle detection assay identifies membrane-associated a-Synuclein as an early-stage biomarker in Parkinson’s disease
Shijun Yan, University of Oxford

Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles Laura Parkkinen, University of Oxford

Structural insight into binding of novel PET tracer MODAG-005 to lipidic 𝛼-Synuclein fibrils
Myeongkyu Kim, Max Planck Institute for Multidisciplinary Sciences

Dual 4R-Tau and α-Synuclein Seed Amplification Assays for Differential Diagnosis of Movement Disorders
Ivan Martinez-Valbuena, Tanz Centre for Research in Neurodegenerative diseases - University of Toronto

Panel Discussion
4:00 PM - 4:30 PM
Refreshments and Day Two Posters
4:30 PM - 6:25 PM Modeling αSyn Pathology in Experimental Models

Moderator: Jia-Yi Li, Department of Experimental Medical Science, Lund University
Alpha-synuclein in Lewy Bodies
Virginia M-Y Lee, The John H. Ware 3rd Endowed Professor in Alzheimer's Research, Director, Centre for Neurodegenerative Disease Research, University of Pennsylvania

Experimental models of MSA
Nadia Stefanova, Professor at Department of Neurology, Medical University of Innsbruck, Austria

Alpha-synuclein causes tau-dependent synaptic deficits: Mechanistic insights for Lewy body dementia
Michael Lee, Center for Neurodegenerative Disease, Institute for Translational Neuroscience, The University of Minnesota

Selected Abstracts:
Network analysis of α-synuclein progression identifies p21-activated kinases as therapeutic targets for Parkinson’s disease
Michael Henderson, Van Andel Institute

Intranasally administered exosomes containing α-synuclein induce behavioural deficits and brain pathology in vivo but are protected by heterozygous Drp1 knockout
Harry Brown, Florida International University

Diabetes-Driven Neurodegeneration: IDE Deficiency and High-Fat Diet as Key Contributors to Parkinson’s Disease Neuropathology
Hugo Vincente Miranda, NOVA University Lisbon

Panel Discussion
7:30 PM - 10:30 PM GALA DINNER
The main dining hall of the world-famous King’s College will host the conference gala dinner, a venue that perfectly befits the importance of Synuclein 2025. Guests will be treated to an exceptional experience against the backdrop of the iconic King’s College Chapel, which took around 100 years to build.

Please note the Gala Dinner is sold out and we have put a waiting list in place.

Friday, April 11, 2025

West Road Concert Hall
8:00 AM - 8:30 AM Fun Run
To mark the occasion of World Parkinson’s Day, we are organising an informal 5k fun run and hope as many people as possible will join in. Meeting point and route details will be provided at the conference
8:30 AM - 1:00 PM
Conference desk opens day 4
9:00 AM - 10:00 AM Time to grab a coffee and have a chat!
10:00 AM - 12:00 PM αSyn Clearance Mechanisms

Moderator: Darren Moore, Department of Neurodegenerative Science, Van Andel Institute

The role of the serine peptidase KLK6 in extracellular alpha-synuclein clearance. Kostas Vekrellis, Research Director, Biomedical Research Foundation Academy of Athens and Visiting Professor, Dept. Of Experimental Medicine, University of Oxford

Therapeutic Potential of the Glymphatic System in the Clearance of Pathological α-Synuclein
Ian Harrison, Principal Research Fellow, University College London

Regulation of α-Synuclein accumulation in cells
Edward, Fon, Scientific Director, Montreal Neurological Institute-Hospital


Selected Abstracts:
Astrocytic degradation pathway disruption and secretome alterations in α-synuclein pathology: implications for dopaminergic neuronal health and function
Indrani Datta, National Institute of Mental Health and Neurosciences (NIMHANS)

Inducing Chaperone-Mediated Autophagy as a Means to Counteract alpha-Synuclein Pathology in Non-Human Primates
Maria Fouka, BRFAA - Biomedical Research Foundation Academy of Athens

Determining how Parkinson’s disease risk genes influence α-synuclein pathology and clearance Cara Croft, Queen Mary University of London

Panel Discussion
12:00 PM - 12:30 PM
Refreshments
12:30 PM - 1:50 PM αSyn Therapies

Moderators: Tiago Fleming Outeiro & Arianna Bellucci

Five minute flash talks

PK7/Syntacasyn: a Synapsin III ligand reducing alpha-synuclein aggregation and exerting significant disease-modifying effects in experimental models of Parkinson’s disease
Francesca Longhena, University of Cambridge

Neuronal-type specific SNCA-targeted epigenome therapy for precision medicine in Synucleinopathies: Preclinical studies
Ornit- Chiba-Falek, Duke University

SNCA-targeting antisense oligonucleotides as a therapeutic approach for alpha-synucleinopathies
Epaminondas Doxakis, Biomedical Research Foundation of the Academy of Athens

Round Table With Industry Leaders

Contributors
Diederik Moechars, Senior Scientific Director at Janssen
Armin Giese, CSO & Founder, MODAG GmbH
Pekka Kallunki, Research Fellow, H. Lundbeck A/s
Can Kayatekin, Sanofi
Simon Stott, Cure Parkinson's

1:50 PM - 2:00 PM
Awards Presentation & Closing Remarks
2:00 PM - 2:30 PM
Grab & Go Lunch
West Road Concert Hall
8:00 AM - 8:30 AM Fun Run
To mark the occasion of World Parkinson’s Day, we are organising an informal 5k fun run and hope as many people as possible will join in. Meeting point and route details will be provided at the conference
8:30 AM - 1:00 PM
Conference desk opens day 4
9:00 AM - 10:00 AM Time to grab a coffee and have a chat!
10:00 AM - 12:00 PM αSyn Clearance Mechanisms

Moderator: Darren Moore, Department of Neurodegenerative Science, Van Andel Institute

The role of the serine peptidase KLK6 in extracellular alpha-synuclein clearance. Kostas Vekrellis, Research Director, Biomedical Research Foundation Academy of Athens and Visiting Professor, Dept. Of Experimental Medicine, University of Oxford

Therapeutic Potential of the Glymphatic System in the Clearance of Pathological α-Synuclein
Ian Harrison, Principal Research Fellow, University College London

Regulation of α-Synuclein accumulation in cells
Edward, Fon, Scientific Director, Montreal Neurological Institute-Hospital


Selected Abstracts:
Astrocytic degradation pathway disruption and secretome alterations in α-synuclein pathology: implications for dopaminergic neuronal health and function
Indrani Datta, National Institute of Mental Health and Neurosciences (NIMHANS)

Inducing Chaperone-Mediated Autophagy as a Means to Counteract alpha-Synuclein Pathology in Non-Human Primates
Maria Fouka, BRFAA - Biomedical Research Foundation Academy of Athens

Determining how Parkinson’s disease risk genes influence α-synuclein pathology and clearance Cara Croft, Queen Mary University of London

Panel Discussion
12:00 PM - 12:30 PM
Refreshments
12:30 PM - 1:50 PM αSyn Therapies

Moderators: Tiago Fleming Outeiro & Arianna Bellucci

Five minute flash talks

PK7/Syntacasyn: a Synapsin III ligand reducing alpha-synuclein aggregation and exerting significant disease-modifying effects in experimental models of Parkinson’s disease
Francesca Longhena, University of Cambridge

Neuronal-type specific SNCA-targeted epigenome therapy for precision medicine in Synucleinopathies: Preclinical studies
Ornit- Chiba-Falek, Duke University

SNCA-targeting antisense oligonucleotides as a therapeutic approach for alpha-synucleinopathies
Epaminondas Doxakis, Biomedical Research Foundation of the Academy of Athens

Round Table With Industry Leaders

Contributors
Diederik Moechars, Senior Scientific Director at Janssen
Armin Giese, CSO & Founder, MODAG GmbH
Pekka Kallunki, Research Fellow, H. Lundbeck A/s
Can Kayatekin, Sanofi
Simon Stott, Cure Parkinson's

1:50 PM - 2:00 PM
Awards Presentation & Closing Remarks
2:00 PM - 2:30 PM
Grab & Go Lunch

West Road Concert Hall
8:00 AM - 8:30 AM Fun Run
To mark the occasion of World Parkinson’s Day, we are organising an informal 5k fun run and hope as many people as possible will join in. Meeting point and route details will be provided at the conference
8:30 AM - 1:00 PM
Conference desk opens day 4
9:00 AM - 10:00 AM Time to grab a coffee and have a chat!
10:00 AM - 12:00 PM αSyn Clearance Mechanisms

Moderator: Darren Moore, Department of Neurodegenerative Science, Van Andel Institute

The role of the serine peptidase KLK6 in extracellular alpha-synuclein clearance. Kostas Vekrellis, Research Director, Biomedical Research Foundation Academy of Athens and Visiting Professor, Dept. Of Experimental Medicine, University of Oxford

Therapeutic Potential of the Glymphatic System in the Clearance of Pathological α-Synuclein
Ian Harrison, Principal Research Fellow, University College London

Regulation of α-Synuclein accumulation in cells
Edward, Fon, Scientific Director, Montreal Neurological Institute-Hospital


Selected Abstracts:
Astrocytic degradation pathway disruption and secretome alterations in α-synuclein pathology: implications for dopaminergic neuronal health and function
Indrani Datta, National Institute of Mental Health and Neurosciences (NIMHANS)

Inducing Chaperone-Mediated Autophagy as a Means to Counteract alpha-Synuclein Pathology in Non-Human Primates
Maria Fouka, BRFAA - Biomedical Research Foundation Academy of Athens

Determining how Parkinson’s disease risk genes influence α-synuclein pathology and clearance Cara Croft, Queen Mary University of London

Panel Discussion
12:00 PM - 12:30 PM
Refreshments
12:30 PM - 1:50 PM αSyn Therapies

Moderators: Tiago Fleming Outeiro & Arianna Bellucci

Five minute flash talks

PK7/Syntacasyn: a Synapsin III ligand reducing alpha-synuclein aggregation and exerting significant disease-modifying effects in experimental models of Parkinson’s disease
Francesca Longhena, University of Cambridge

Neuronal-type specific SNCA-targeted epigenome therapy for precision medicine in Synucleinopathies: Preclinical studies
Ornit- Chiba-Falek, Duke University

SNCA-targeting antisense oligonucleotides as a therapeutic approach for alpha-synucleinopathies
Epaminondas Doxakis, Biomedical Research Foundation of the Academy of Athens

Round Table With Industry Leaders

Contributors
Diederik Moechars, Senior Scientific Director at Janssen
Armin Giese, CSO & Founder, MODAG GmbH
Pekka Kallunki, Research Fellow, H. Lundbeck A/s
Can Kayatekin, Sanofi
Simon Stott, Cure Parkinson's

1:50 PM - 2:00 PM
Awards Presentation & Closing Remarks
2:00 PM - 2:30 PM
Grab & Go Lunch

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