Pathological Assembly
| Wednesday, April 9, 2025 |
| 10:30 AM - 12:00 PM |
Overview
Moderator: Claudio Fernandez, MPLbioR (CEI-UNR/MPINAT-MPG)
Cryo-EM structures of alpha-synuclein filaments from the human brain.
Michel Goedert, Group Leader, MRC Laboratory of Molecular Biology
Alpha-synuclein aggregates polymorphism and the structural molecular basis of distinct synucleinopathies.
Ronald Melki, Research Director, CNRS; Institut Francois Jacob (MIRCen), CEA
Selected Abstracts:
Resolving heterogeneity of Lewy Bodies with spatial proteomics
Marc Oeller, Max Planck Institute of Biochemistry
Tuning the aggregation landscape of alpha-synuclein by the specific binding of a molecular probe to master controller sequences
Phelippe Do Carmo Gonçalves, Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario (MPLbioR, UNR-MPINAT)
Investigating the “structure-function” relationship of the intrinsically disordered regions of alpha-synuclein amyloid fibrils
Liam Aubrey, University of Leeds
Panel Discussion
Speaker
Dr Claudio Oscar Fernandez
Director
MPLbioR (CEI-UNR/MPINAT-MPG)
PATHOLOGICAL ASSEMBLY
10:30 AM - 12:00 PM
Dr Michel Goedert
Programme Leader
MRC Laboratory of Molecular Biology
Cryo-EM structures of alpha-synuclein filaments from the human brain.
10:30 AM - 10:50 AM
Dr Ronald Melki
Research Director, CNRS
Commissariat à l'Énergie Atomique
Alpha-synuclein aggregates polymorphism and the structural molecular basis of distinct synucleinopathies.
10:50 AM - 11:10 AM
Dr Marc Oeller
Postdoctoral Fellow
Max Planck Institute Of Biochemistry
Resolving heterogeneity of Lewy Bodies with spatial proteomics
11:10 AM - 11:22 AM
Dr Phelippe Do Carmo Gonçalves
Post Doc
MPLbioR (CEI-UNR / MPINAT-MPG)
Tuning the aggregation landscape of alpha-synuclein by the specific binding of a molecular probe to master controller sequences
11:22 AM - 11:34 AM
Dr Liam Aubrey
Postdoc
University Of Leeds
Investigating the “structure-function” relationship of the intrinsically disordered regions of alpha-synuclein amyloid fibrils
11:34 AM - 11:46 AM
