Advanced Microscopy for Studying Synucleinopathies

Wednesday, April 9, 2025
3:45 PM - 5:30 PM

Overview


Moderators: Uri Ashery, Tel Aviv University

Super-resolution imaging
David Klenermann, Professor of Biophysical Chemistry, University of Cambridge

Cryo ET
Ruben Fernandez-Busnadiego, Professor, Institute of Neuropathology, University of Göttingen

A cellular perspective on alpha-synuclein pathology in the human brain
Wilma van de Berg, Senior Neuroscientist & Associate Professor, University of Amsterdam

Selected Abstracts:
Two-photon and confocal microscopy plus MRI and PET analysis disclose the earliest synaptic/connectome changes associated with pathological alpha-synuclein deposition
Gaia Faustini, University of Brescia

New pathological phenotype identified in MSA post-mortem human brain using CLEM
Amanda Lewis, Laboratory of Biological Electron Microscopy, EPFL and Department of Fundamental Microbiology, UNIL

Unveiling alpha-Synuclein Assemblies: Modeling and Cutting-Edge Imaging Techniques to Unravel Disease Mechanisms
Diana Lazaro, University of Pennsylvania

Panel Discussion


Speaker

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Prof Uri Ashery
Pi
Tel Aviv University

Advanced microscopy for studying synucleinopathies

3:45 PM - 5:30 PM
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Professor Sir David Klenerman
Professor of Biophysical Chemistry
University of Cambridge

Super-resolution imaging

3:45 PM - 4:05 PM
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Prof. Dr. Ruben Fernandez-Busnadiego
University Medical Centre Göttingen

Cryo ET

4:05 PM - 4:25 PM
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Dr. Wilma D.J. Van De Berg
Associate Professor, Chair Clinical Neuroanatomy And Biobanking
Amsterdam Umc, Vrije University Amsterdam

A cellular perspective on alpha-synuclein pathology in the human brain

4:25 PM - 4:45 PM
Dr Gaia Faustini
University Of Brescia

Two-photon and confocal microscopy plus MRI and PET analysis disclose the earliest synaptic/connectome changes associated with pathological alpha-synuclein deposition

4:45 PM - 4:57 PM
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Dr Amanda Lewis
Senior Scientist
EPFL, Switzerland

New pathological phenotype identified in MSA post-mortem human brain using CLEM

4:57 PM - 5:09 PM
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Dr. Diana Lázaro
Postdoc
University Of Pennsylvania

Unveiling alpha-Synuclein Assemblies: Modeling and Cutting-Edge Imaging Techniques to Unravel Disease Mechanisms

5:09 PM - 5:21 PM
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